November 2008 Meeting

Triple Quadrupole Mass Spectrometry for Target Compounds Analysis in Food, Environmental, and Biomedical Applications

The November 2008 CSSC meeting will be held at the 95 Gathering Place in Wallingford, CT.  The meeting will feature a technical presentation by Dr. Hans-Joachim Hübschmann, from Thermo Scientific, Bremen, Germany as well as dinner. The cost of the meeting is $30 ($15 Students and Emeritus) and is to be paid at the event. This meeting will be the CSSC annual meeting and a vote for the Officers of Board of Directors and the Board of Directors will be held at the meeting.

Registration deadline is Thursday, November 20th 2008 .

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Abstract:  

Triple Quadrupole Mass Spectrometry: Unique Selectivity for Fast Multiple Target Compound Analysis in Food, Environmental, and Biomedical Applications.

Dr. Hans-Joachim Hübschmann, the author of the “Handbook of GC/MS: Fundamentals and Applications” (Wiley, 2008, 2nd Ed.) and GC/MS Technology Manager at Thermo Fisher Scientific in Bremen, Germany, will present overview of applications from the cutting edge triple quadrupole mass spectrometry technology, including discussion of highly resolved precursor ion selection (H-SRM), fast acquisition speeds for up to 3000 SRMs in one run, triggering data-dependant full scan MS/MS (with dynamic exclusion) and the data dependent acquisition modes for a Quantitation-Enhanced MS/MS Detection (QED-MS/MS), and reversed energy ramp (RER) generation of MSMS spectra for the simultaneous quantitation and structural confirmation.  Use of H-SRM triggered product ion scans on the TSQ Quantum Access minimizes the potential for “false positive” results, especially when analyzing complex samples.  The “500 pesticides method” using TSQ Quantum GC will be presented as an example of a highly sensitive and fast multi component analysis.  The large HPLC injection volume capabilities (1 mL to 20 mL), eliminating the need for laborious and expensive offline pre-concentration will be discussed in context of LC-MS/MS Analysis of Herbicides in Drinking Water at femtogram levels.  The application of Reversed Energy Ramp scan function using static collision energy will be exemplified on data from monitoring of active substances and their metabolites in complex matrices from serum, blood, and urine.  Lastly, some data on metabolomics work will be presented in a comparative fashion between triple quad and high resolution mass spectrometry technologies.

Biography:

Hans-Joachim Hübschmann graduated in Food Chemistry from the Technical University, Berlin, Germany. His scientific research interest covered the GC and LC/MS trace analysis of pesticides and the determination of anabolic agents in food.   In his current position with Thermo Fisher Scientific as Technology Manager GC/MS for high resolution and triple quadrupole GC/MS systems, located in Bremen, Germany and Austin TX, USA. Hans is with Thermo Fisher Scientific since 1984, at that time known as Finnigan MAT Bremen in different national and international positions as application scientist, sales manager, and product manager.

95 Gathering Place
865 North Colony Road
Wallingford, CT 06492
(203) 265-1552

Last Updated:  11/04/2008 07:15 PM