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June 2003 Meeting |
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LC-NMR-MS Methods |
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Date: | Tuesday, June 24, 2003 | |||||||
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Location: | University
of Connecticut Nathan Hale Inn and Conference Center Storrs, CT |
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Speaker: | P. Stone Wilkinson,
Ph.D. Bruker Biospin Corporation, Billerica, MA USA |
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Agenda: | 5:30 - 6:30 PM Registration/Social
Hour 6:30 - 7:30 PM Dinner 7:30 - 8:30 PM Presentation |
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Cost: | $25 ($15 Students and Emeritus) | |||||||
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Registration Deadline: |
Friday, June 20, 2003 | |||||||
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| Abstract: Traditional methods of identifying components in a mixture normally involve isolation of the components of interest. If a component is labile, it may decompose or rearrange during the isolation procedure. Multiple preparatory chromatographic separations may be necessary to provide a sufficient quantity of sample for NMR analysis in a 5mm NMR tube. The coupling of an analytical HPLC and detector with an NMR was the first step in the development of hyphenated NMR technologies. LC-NMR analysis of components eliminates the need for isolation and NMR data may be acquired on many components within a single chromatographic run. The addition of a mass spectrometer to an LC-NMR system provides two primary functions; the acquisition of a mass spectrum of the individual components and the highly selective nature of mass spectroscopy is used as a discriminating factor for peaks prior to NMR analysis. MSn measurements are possible with the incorporation of a specialized LC-NMR-MS interface. A complete description of the LC-NMR and LC-NMR-MS hardware and working modes will be presented. | |||||||||
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| Biography: P. Stone Wilkinson received a Bachelor of Science in Chemistry from the University of New Hampshire in 1988, and completed a Ph.D. in Organic Chemistry in 1993 at Brandeis University. Currently, Dr. Wilkinson is employed by Bruker Biospin as a National NMR Applications Manager. | |||||||||
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| Directions: General Directions to the UCONN's Nathan Hale Inn & Conference Center For directions and parking, please assess their web site: http://www.nathanhaleinn.com/ Telephone (860)427-7888 Fax (860)427-7850 Rhode Island: Take Route 6 West into North Windham. Once in North Windham (past Wal-Mart) take a right onto Route 6 West, take the 1st exit. At the end of the ramp take a right. At the next light take a left onto Route 195 North. Proceed straight for approximately 10 minutes. Take a left onto Mansfield Road (near Fine Arts Complex). Proceed straight to the first stop sign; take a left onto Gilbert Road. Take the 2nd left and the Hotel will be straight ahead. Stamford: Take 95 North to 91 North to 84 East. From 84 East, get off at exit 68. Once off exit make a right onto 195 South. Proceed straight for approximately 10 minutes. Once on UConn campus take a right onto Mansfield Road. Proceed straight to 1st stop sign; take a left onto Gilbert Road. Take the 2nd left and the Hotel will be straight ahead. Boston: Take 90 West to 84 West. From 84 West, get off at exit 68. Once off exit make a left onto 195 South. Proceed straight ahead for approximately 10 minutes. Once on UConn campus take a right onto Mansfield Road. Proceed straight to 1st stop sign; take a left onto Gilbert Road. Take the 2nd left and the Hotel will be straight ahead. Springfield/Holyoke: Take 91 South to 84 East. From 84 East, get off at exit 68. Once off exit make a right onto 195 South. Proceed straight ahead for approximately 10 minutes. Once on UConn campus take a right onto Mansfield Road. Proceed straight to 1st stop sign; take a left onto Gilbert Road. Take the 2nd left and the Hotel will be straight ahead. Bradley International Airport: From the airport, take 91 South to 84 East. From 84 East, get off exit 68. Once off exit make a right onto 195 South. Proceed straight for approximately 10 minutes. Once on UConn campus take a right onto Mansfield Road. Proceed straight to 1st stop sign; take a left onto Gilbert Road. Take the 2nd left and the Hotel will be straight ahead. 84 West: Take exit 68 off of 84 West, from 84 West get off exit 68. Once off exit make a left onto 195 South. Proceed straight for approximately 10 minutes. Once on UConn campus take a right onto Mansfield Road. Proceed straight to 1st stop sign; take a left onto Gilbert Road. Take the 2nd left and the Hotel will be straight ahead. 84 East (Hartford): From 84 East get off exit 68. Once off exit make a right onto 195 South. Proceed straight for approximately 10 minutes. Once on UConn campus take a right onto Mansfield Road. Proceed straight to 1st stop sign; take a left onto Gilbert Road. Take the 2nd left and the Hotel will be straight ahead. |
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