January 2006 Meeting

Retention of Polar and Nonpolar Compounds
on the Same LC Column and Other Unique Capabilities
of Hydride-Based Stationary Phases

The January 2006 CSSC meeting will be held at
Pfizer Global Research and Development in Groton, CT.
The cost of the meeting is $30 ($20 Students and Emeritus),
and is to be paid at the day of the event.

You must be pre-registered by the Registration Deadline
with Pfizer Security in order to attend!

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Click here for a printable version of this announcement

Abstract:  The surface of hydride-based stationary phases creates a separation medium that possesses unique properties when compared to ordinary silica. The modes of separation which are possible include reversed phase, aqueous normal phase and organic normal phase. The three modes are generally found to some degree on all hydride stationary phases encompassing a range of organic moieties attached to the surface. Another feature is the ability to utilize mobile phases ranging from 100% aqueous to completely organic for the analysis of ionic/polar compounds as well as solutes that are highly hydrophobic. Most stationary phases that are based on ordinary silica normally are capable of providing only a single retention mechanism depending on the organic group bonded to the surface. For hydride materials in the aqueous normal phase bases are retained under acidic conditions in high organic content mobile phases so it is not necessary to use high pH eluents that can damage many instrumental components such as pumps and valves. A hydride material having an organic moiety bonded to the surface can even function in the organic normal phase mode, i.e. compounds with polar/ionic functional groups are retained in mobile phases such as hexane/ethyl acetate. Another property of stationary phases with hydride surfaces is their rapid equilibration after a gradient. In a typical reversed-phase gradient with hydrophobic solutes, reproducible retention times are found after only one minute of equilibration between runs. Because of the multimodal capabilities of the hydride materials, reverse gradients (from high organic content to a more polar composition in the mobile phase) can also be run for selective retention and elution of polar compounds. This presentation will discuss some of the fundamental properties of hydride-based separation materials and describe a variety of applications that utilize one or more of the three retention mechanisms. 

Biography: Joseph J. Pesek received his B.S. degree in Chemistry from the University of Illinois, Urbana, Champaign and his Ph.D. in Analytical Chemistry from the University of California, Los Angeles. He did a one-year postdoctoral fellowship at UCLA before becoming Assistant Professor of Chemistry at Northern Illinois University. He then moved to San Jose State University becoming Professor of Chemistry and has also served as Department Chair, and Dean for Graduate Studies and Research. He was selected the President’s Scholar at San Jose State in 1993 for his research productivity and contributions to the development of graduate students. He was named a Camille and Henry Dreyfus Foundation Scholar in 1993 and again in 2001. He was the project director for the development of the W.M. Keck Facility for Chemical Research at San Jose State. He has had sabbatical leaves in Paris (with Georges Guiochon) and Marseille (Tony Siouffi), France as well as Melbourne (Milton Hearn), Australia. He has over 160 publications, 3 books, 3 patents and has made over 200 presentations at a variety of symposia and meetings. He has served as a consultant to pharmaceutical and instrumental companies, commercial analytical laboratories and intellectual property law firms. His research interests are in the development, characterization and applications of separation materials for chromatographic and electrophoretic processes. 

From I-95 North:  Take Exit 87 (Clearance B. Sharpe Highway Rt. 349).  At the second set of traffic lights turn right on Rt. 349 South(Poquonnock Rd).  At the first set of traffic lights turn left on to Benham Rd. Proceed to the first set of traffic lights. Turn left to Pfizer's North Gate (The Hess station will be across the street).  The guard will provide you with your badge and direct you to the parking garage. Once you are in the garage the main entrance to Building 220 is on level 2.  The meeting will be held in the Building 200 Cafeteria -- Rotunda B.  Registration will be held at the bottom of the escalators at the cafeteria entrance.

From I-95 South:  Take Exit 87 (Clearance B. Sharpe Highway Rt. 349).  At the second set of traffic lights turn right on Rt. 349 South(Poquonnock Rd).  At the first set of traffic lights turn left on to Benham Rd. Proceed to the first set of traffic lights.  Turn left to Pfizer's North Gate (The Hess station will be across the street).  The guard will provide you with your badge and direct you to the parking garage. Once you are in the garage the main entrance to Building 220 is on level 2.  A guard at the entrance will direct you to the meeting.  The meeting will be held in the Building 200 Cafeteria -- Rotunda B.  Registration will be held at the bottom of the escalators at the cafeteria entrance.

Pfizer Global Research and Development
Groton Laboratories
Eastern Point Road
Groton, CT 06340

Visitor’s Center Phone (860) 441-4000

Last Updated:  04/14/2006 01:24 PM